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What's a 'Normal' A1C? When Is It Misleading?

Key Takeaways:


  • A1C is a type of blood glucose test that measures your average blood sugar levels over 2-3 months.
  • The A1C test can be a useful measurement for diabetes management and a screening tool to help diagnose prediabetes and diabetes.
  • Factors that can misleadingly affect A1C include certain health conditions, pregnancy, and medications.


Hemoglobin A1C (aka HbA1C or just A1C) is the standard for measuring blood sugar in people with diabetes. An A1C test reflects your average glucose levels over two to three months.


Studies have found higher A1C levels are associated with an increased risk of diabetes complications such as heart problems, kidney disease, and diabetic neuropathy (nerve disease). For every 1% decrease in A1C, there is significant protection against those complications.


However, as an average over a period of months, A1C cannot capture critical information such as time in range (70-180 mg/dL) and time below range (less than 70 mg/dL). So, why is A1C used in the first place? Here's what an A1C test is helpful for, as well as factors that can lead to misleadingly high or low values. 



What is A1C and why is it used?

A1C is a type of blood test that estimates a person’s average blood sugar levels over two to three months. Since it captures blood glucose levels over a period of time, an A1C test can be a useful tool for diabetes management. A1C can also be used as a screening tool to help diagnose prediabetes and diabetes (elevated A1C levels over time can be an indicator of diabetes). 


A1C is usually measured in a lab with routine blood work, or with a countertop machine in a doctor’s office (and some pharmacies) using a fingerstick.


An A1C test measures the relative percentage of what's called “glycated hemoglobin,” which refers to how much hemoglobin (an important component of red blood cells) has sugar attached. If a person consistently has higher blood glucose levels, A1C will go up because more red blood cells are coated with sugar. Once a red blood cell becomes coated with sugar, the link is irreversible; it's only when red blood cells are "recycled" (which happens every two to three months) that the sugar coating disappears. 


Though A1C doesn’t provide day-to-day or hour-to-hour information as continuous glucose monitoring (CGM) does, it's still helpful for understanding how well your diabetes treatment plan is working over time. 


It can also be helpful for determining your risk of diabetes-related complications. For example, a lower A1C is correlated with a lower risk of microvascular complications, such as kidney disease, vision loss (retinopathy), and nerve damage. Similarly, a consistently high A1C can lead to macrovascular complications like heart disease.



What are “normal” A1C levels?

Generally, a high A1C value indicates high average blood sugar levels – that means you might be at risk for or already have diabetes. Here are the following cutoffs for A1C per the American Diabetes Association:

A table showing aic level and what it means

Screening is critical to the prevention or early diagnosis of diabetes; make sure to get an A1C test if you think you might be at risk for diabetes.



For people who have diabetes, an A1C of less than 7% is the goal. Since each person with diabetes is unique, however, healthcare providers are recommended to set individual goals as A1Cs may differ depending on age and other health conditions. 


How does age affect A1C?

Research is conflicting on this topic, but some studies have found that A1C increases with age in people who don't have diabetes. For people with diabetes, it may not necessarily be A1C changing with age but due to changes in diabetes management strategies.


For example, younger people may be more focused on reducing long-term health complications, while older people may concentrate on avoiding severe hypoglycemia (low blood sugar). Again, this all depends on your unique biology and any other underlying health conditions; talk with a healthcare professional if you're curious about how age may affect your A1C levels.



Where is A1C misleading or potentially inaccurate?

Much progress has been made in standardizing and improving the accuracy of the A1C test thanks to the National Glycohemoglobin Standardization Program (NGSP). Results from a non-NGSP certified lab may not be as reliable. 


Depending on the machine, a single A1C test can have up to a 0.5% margin of error, which means the “true” value might be 0.5% higher or lower than the measured A1C. For example, if a lab report shows an A1C value of 7%, the actual A1C value might range from 6.5% to 7.5%.


As mentioned, A1C is based on a person’s red blood cell turnover (the lifespan of a red blood cell) and the quantity of sugar attached to each cell. Many factors can impact A1C and red blood cell turnover including certain conditions (like kidney disease), hemoglobin variants, types of anemia, and certain drugs and vitamins. This can result in misleading A1C values. 


The relationship between A1C values and average blood sugar levels can also vary markedly from person to person. In studies using CGM, 24/7 blood sugar levels can be compared to a measured A1C. These studies reveal considerable variation between participants. For instance, an 8% A1C value in one person could reflect an average blood sugar of 140 mg/dL, while in another it could be 220 mg/dL. 

A graph showing mean cgm glucose by a1c

A1C to blood sugar conversion

Calculating A1C to blood sugar, or estimated average glucose (eAG), is done through a mathematical equation. If you know your A1C values you can find out how that translates to blood glucose using a conversion calculator. Results can vary, but here's a quick look:

A table with a lot of numbers on it

For looking at an individual’s glucose values, CGM is a better tool for measuring average sugar levels, time in range, and time below range. 



What tools are available if an A1C test is not accurate or sufficient?

Besides A1C tests, the most common measures of blood sugar are the oral glucose tolerance test (OGTT), CGM, and self-monitored blood glucose tests.


The OGTT is a diagnostic tool for diabetes and prediabetes that assesses a person’s response to consuming a fixed amount of sugar. Two hours after taking a sugar drink, blood sugar levels are measured. 


Below 140 mg/dL is considered “normal,” between 140 mg/dL and 200 mg/dL points to prediabetes or impaired glucose tolerance, and above 200 mg/dL indicates diabetes. The OGTT is not useful for tracking diabetes management.


For people with diabetes, CGM has the advantage of monitoring blood sugar levels consistently throughout the day (every 5-15 minutes), which provides more detailed insights into time in range, low blood sugar, and hyperglycemia (high blood sugar).


If CGM is not available, taking frequent fingersticks with a blood glucose meter – when waking up, before and after meals, and before bed – can also indicate when blood sugar levels are going low, high, or staying in range. 



A diagram showing the levels of hemoglobin a1c

What else can affect A1C?

While there are many unsuspecting things that can impact A1C, that doesn't invalidate the test results. Rather, knowing how certain factors can change A1C levels is a key part of using it as one measure of diabetes management. Here are some other non-glycemic factors that can affect A1C results.



Untreated anemia

Many of the conditions that affect A1C results are related to changes in the turnover of red blood cells, and thus notably, types of anemia. Untreated anemia can be caused by an iron or vitamin B12 deficiency. 


Untreated anemia can misleadingly increase A1C values due to decreased production of red blood cells. To test for anemia, ask your healthcare provider about taking a complete blood count (CBC) test. Correction of anemia through treatment can also affect A1C results.


Asplenia (decreased spleen function)

The spleen is involved in the production and removal of red blood cells. Decreased spleen function may be caused by surgery, congenital disorders, and other blood disorders such as sickle cell disease. This may lead to misleadingly increased A1C. Asplenia can be identified by MRI, echocardiogram, chest X-ray, or a screening test.



Blood loss and blood transfusions

The body’s response to recent blood loss (creating more blood cells) or blood transfusion can misleadingly lower A1C, but the next A1C test should return to a more representative reading. Let your healthcare provider know if you have recently received a blood transfusion.

Cirrhosis of the liver

Cirrhosis refers to chronic liver damage that leads to scarring. Cirrhosis, in addition to affecting response to glucose-lowering medications (including insulin), may misleadingly lower A1C values. If you live with or are showing signs of liver damage, ask your healthcare provider about a liver examination.



Hemoglobinopathy and thalassemia

Hemoglobinopathy results in abnormal hemoglobin. Thalassemia refers to the lower production of functional hemoglobin. Depending on the abnormal form of the hemoglobin, hemoglobinopathy can result in either increased or decreased A1C values. Thalassemia can misleadingly lower A1C values due to the early destruction of red blood cells. Tell your healthcare provider if you have any known family members that have had thalassemia.


Hemolysis (rapid destruction of red blood cells)

Hemolysis is the rapid destruction of red blood cells, which may misleadingly lower A1C values due to the shortened red blood cell lifespan. This condition may be caused by an inappropriate immune response or artificial heart valves. 



Untreated hypothyroidism 

Hypothyroidism (low levels of thyroid hormone) may misleadingly increase A1C, while treatment with thyroid hormone can lower A1C. It's always a good idea to have your thyroid function measured during a routine blood test.

Pregnancy

Decreased red blood cell lifespan and an increase in red blood cell production may misleadingly lower A1C values in both early and late pregnancy. Ask about taking an oral glucose tolerance test, which is used to diagnose gestational diabetes. A common practice for pregnant people with diabetes is to use CGM.



Uremia

Uremia refers to high levels of waste normally filtered by kidneys in the blood. Untreated uremia may misleadingly increase A1C values. Dialysis is used to treat uremia – in this case, A1C is not a suitable test. 


Medications

Certain medications that may misleadingly increase A1C include:


  • Opioids (pain relievers): Duragesic (fentanyl), Norco/Vicodin (hydrocodone), Dilaudid (hydromorphone), Astramorph/Avinza (morphine), or OxyContin/Percocet (oxycodone)
  • Long-term use of over 500 mg of aspirin per day 


Medications that may misleadingly lower A1C include:


  • Erythropoietin (EPO)
  • Azcone (dapsone)
  • Virazole/Rebetol/Copegus (ribavirin)
  • HIV medications (NRTIs): Emtriva, Epivir, Retrovir, Videx-EC, Viread, Zerit, or Ziagen


Always discuss the appropriate use of opioids for pain and their possible effect on A1C as well. Tell your healthcare provider if you are taking any of these medications prior to your A1C test.



The bottom line 

If you have diabetes, it’s also important to take the perspective that A1C is not a “grade” on diabetes management, but rather a helpful measurement tool that you and your healthcare providers can use to guide decisions and assess the risk of complications.

Credited: [Author: Jeemin Kwon], [Source: diaTribe Learn MAKING SENSE OF DIABETES | What's a 'Normal' A1C? When Is It Misleading?]

Healthy Bites

February 12, 2025
Marcia Kadanoff, who lives with type 2 diabetes, shares her top five tips for enjoying a Valentine’s Day meal out. Pink and red hearts everywhere, overpriced dinners, wondering if you’ll have a date (or if you got your partner an appropriate gift) – ah, the joys of Valentine’s Day. I’m stressed just thinking about it. As a person with diabetes, my stress may be a bit different than general Valentine’s Day anxiety. By this point, my spouse knows enough not to get me chocolates, my biggest landmine food. But the hard thing for Valentine's Day or any other romantic occasion is getting a reservation at the right kind of restaurant and – as always when living with diabetes – planning out my meal. Special occasion meals take special skills to navigate. The good news is that there are definitely strategies that can help make a romantic dinner somewhere special enjoyable without diabetes taking center stage. Where I live – the San Francisco Bay Area – many restaurants have Valentine’s Day dinner specials that consist of three to five courses. There’s nothing wrong with eating a multi-course meal, but it does make diabetes management more difficult. From bread to creamy soups and crouton-laden salads to heavy entrées to a dessert that’s potentially cake-filled, multi-course meals can quickly add up to a large amount of carbohydrates, which is a major driver of high blood sugars. The reality is that even if I choose the “healthier” set menu for a celebratory multi-course meal, I still make a point to think about what each portion is bringing (quite literally) to the table. Here are my best tips for navigating a Valentine's Day dinner out.
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January 6, 2025
Key takeaways: U.S. News & World Report has released its 2025 list of best diets, including top-ranked diets for people with diabetes. The list includes nutritious eating patterns such as the Mediterranean diet, the DASH Diet, and the MIND Diet. These dietary eating patterns are optimal for people who are trying to keep blood sugar levels stable. For people living with diabetes, it’s important to eat in ways that help keep blood glucose levels within normal range consistently throughout the day, rather than rapidly fluctuating between figures that are high and low. This often translates to a focus on eating regular, portion-mindful meals that feature lean sources of protein and whole foods plentiful in fiber, along with limiting food or drinks that are high in sugar or simple carbohydrates. U.S. News & World Report issues a list of top diets at the start of each year, with a ranking of their favorites in various health categories, including diabetes and prediabetes. Below are the top four results for the diabetes category, listed in ranked order – plus a bonus honorable mention from the editorial team at diaTribe. While all of these diets – better described as meal patterns – favor whole foods as well as minimize added sugars and refined carbohydrates, their approaches vary. All of these diets, however, have been shown to help improve blood sugar levels while providing adequate nutrition. 1. The Mediterranean diet The Mediterranean eating pattern focuses on consuming an abundance of vegetables, fruits, legumes, beans, nuts, and seeds with low to no red meat intake. It also encourages whole grains, extra virgin olive oil as a main source of healthy fat, moderate amounts of fish rich in omega-3 fatty acids (such as salmon or tuna), and cheese and yogurt . Sweets should be consumed sparingly, if at all. Benefits of the Mediterranean diet Studies have shown that the Mediterranean diet can improve insulin sensitivity, help regulate blood sugar, reduce A1C levels , and lower the risk of type 2 diabetes. Notable health organizations, including the American Heart Association (AHA) and the American Diabetes Association (ADA), have endorsed the Mediterranean diet. What’s more, the Mediterranean diet adds flexibility. “The Mediterranean meal pattern is based on a general pattern of eating that can be adapted to different cultural traditions and food preferences,” said Daisy Seremba, a Georgia-based registered dietitian and certified diabetes care and education specialist. “There are no exclusions of specific foods or food groups, making it easy to follow long term and maintain the health benefits it offers.” Drawbacks of the Mediterranean diet The Mediterranean diet offers many benefits and is an excellent option for most people, but cost may be a concern. “Some consumers report the cost of such things as olive oil, fish, nuts, and seeds may be prohibitive for their budgets,” Seremba said. She recommends shopping for frozen fish or canned varieties, which confer many of the same benefits, as a way to save on the cost of purchasing items such as fresh seafood. Those on the Mediterranean diet may also need to be mindful of carbohydrate content. “Because the Mediterranean diet promotes the intake of fruits, vegetables, and whole grains, people with diabetes may need additional guidance from a registered dietitian or diabetes care and education specialist to ensure they are following their meal plan and limiting their carb intake as needed,” Seremba said. 2. The flexitarian diet The flexitarian eating pattern is a mix between vegan and vegetarian with the flexibility to consume animal products in limited amounts. The majority of foods eaten are plants, nuts, seeds, whole grains, legumes, fruits, and vegetables. It includes three stages: The first stage limits meat to two days per week with no more than 28 ounces per week. The second stage consists of consuming more plant-based foods (eggs and dairy are allowed) three to four times per week, with less than 18 ounces of meat weekly. The third stage limits meat to no more than 9 ounces per week. If you follow the flexitarian diet, you’ll primarily eat plant-based foods, with occasional lean, organic, grass-fed or pasture-raised meat, poultry, eggs, dairy, and fish. Benefits of the flexitarian diet “The flexitarian eating pattern encourages consumption of more plants as the base of the diet with less emphasis on consuming meat, which is more environmentally friendly and healthier in terms of saturated fat content. In addition, a flexitarian diet is higher in fiber, fruits, and vegetables than the typical or standard American diet,” said Sue-Ellen Anderson-Haynes, a registered dietitian and national spokesperson for the Academy of Nutrition and Dietetics. Anderson-Haynes said the flexitarian diet may be a good option for people with diabetes. She pointed to a 2019 study showing that people who closely followed plant-based dietary patterns had a 13% lower risk of developing type 2 diabetes, compared to those who did not strictly follow a plant-based diet. “Plant-based diets, such as the flexitarian diet, are plentiful in fiber, antioxidants, magnesium, and other nutrients that are well documented in research to assist with the prevention and management of chronic illness such as heart disease, cancer, and diabetes,” said Anderson-Haynes. “In terms of managing diabetes, plant-based diets have shown promising results to slow down complications related to diabetes,” Anderson-Haynes said. “Conversely, research reports that diets high in animal protein increase diabetes risk.” Drawbacks of the flexitarian diet The flexitarian diet imposes no limits on the amount of eggs or dairy consumed. "There is no true limit on eggs and dairy as there is with meat, so people following this diet may not know how much of these foods to limit or to consume,” Anderson-Haynes said. 3. The MIND diet The MIND eating pattern, which stands for Mediterranean-DASH Intervention for Neurodegenerative Delay, is a combination of the Mediterranean and DASH eating patterns. The MIND diet encourages people to consume vegetables, nuts, olive oil, whole grains, berries, fish, beans, poultry, and wine in moderate amounts, although newer studies recommend against having any amount of alcohol). Benefits of the MIND diet Both the Mediterranean and DASH eating patterns have been shown to positively impact the management of diabetes and its comorbidities, including high blood pressure, cardiovascular disease (CVD), high blood cholesterol, and obesity. Several studies also suggest that MIND can slow the progression of Alzheimer's disease, although the specific nutritional components responsible for these possible benefits or their mechanism of action haven’t been well studied. “Several studies suggest that healthy fats, like omegas in olive oil and phytochemicals in berries, might be responsible for the neuroprotective effects,” said Sandra J. Arévalo Valencia, a CDCES and director of community health and wellness at Montefiore Nyack Hospital in New York. “In addition to reducing the risk of mental illness, it can help control weight, improve glycemia, improve cholesterol levels, and reduce hypertension,” Valencia said. “MIND doesn’t restrict any food groups, allowing for well-balanced meal plans that can be followed long term without causing any dietary insufficiencies.” Drawbacks of the MIND diet “When talking about MIND with my patients with diabetes, I recommend they exercise caution with the amount of fruit and nuts they consume. Excessive fruit intake could increase glycemia (blood glucose levels),” Valencia said. “In addition, the high fat content of nuts could cause weight gain. The fact that you are eating good fats doesn't take away from the reality that all fats are high in calories.” As with the Mediterranean eating pattern, Aravelo said MIND can be expensive, as ingredients such as fresh berries, olive oil, avocados, salmon, and other recommended foods tend to be costly. 4. The DASH diet DASH – which stands for Dietary Approaches to Stop Hypertension – emphasizes healthy foods like fruits , vegetables, whole grains, lean proteins, and low-fat dairy, while discouraging red meat, added salt, sugar, or saturated fat. This eating pattern is a flexible, heart-healthy diet that can help manage high blood pressure and prevent cardiovascular disease. Eating the DASH way results in a nutrient-dense meal plan high in potassium, calcium, magnesium, fiber, and protein; the ADA has published a consensus report on the effectiveness of the DASH meal plan for people with diabetes. Benefits of the DASH diet In addition to promoting blood pressure control, this eating pattern has been shown to improve insulin resistance, high cholesterol, and obesity, said Kari Garner, a South Carolina-based registered dietitian and CDCES. Garner pointed to a 2022 study that linked the DASH diet to lower mortality risk among individuals with diabetes. “The DASH diet encourages the intake of nutrient- and fiber-rich foods, which can promote weight loss and decrease blood pressure and cholesterol. The DASH diet also has cardiovascular benefits similar to the Mediterranean diet,” Garner said. Drawbacks of the DASH diet One challenge of DASH is that more than 50% of the calories come from carbohydrates, which may be too high for some people with diabetes. DASH carbohydrates may range between 180-270 grams per day, depending on the calorie level. There’s also the challenge of keeping sodium to below 2,300 milligrams (less than 1 teaspoon) per day. “DASH may be hard to sustain due to perceived lack of flavor in foods,” Garner said, adding that limited culinary skills, affordability of fresh ingredients, and lack of an organized support system as other possible impediments to success on DASH. 5. diaTribe honorable mention: The vegan diet This diet, which came in at number seven, didn’t make it to the top of the U.S. News rankings in 2025. Nevertheless, diaTribe believes it deserves special mention for its noted preventative benefits to the heart and liver, parts of the body that are especially important to care for to avoid complications with diabetes, as well as to the gut microbiome. Following a vegan eating pattern means eliminating all animal products from your diet – no meat, fish, or dairy. Some vegans also exclude honey and gelatin from their diet. This eating pattern focuses on primarily eating grains, fruits, vegetables, legumes, nuts, and seeds. While the vegan diet is certainly more limited than a vegetarian diet, there are many new plant-based protein sources offered at grocery stores, restaurants, and even major chains across the U.S. Benefits of the vegan diet Unlike other diets, the vegan diet has fairly straightforward requirements: all plant foods are included. As long as it comes from a plant, you can eat it. There are no strict limits on the number of calories or the amount of food you eat. Vegan diets are generally high in fiber and low in saturated fats, so they fit within a heart-healthy diet and align well with dietary guidelines for people with diabetes. A small study of people with type 1 diabetes found that the vegan diet delivered several benefits, including reduced total daily insulin dose, improved insulin sensitivity, and weight loss. Research suggests following a plant-based diet can reduce the risk of several chronic conditions, including CVD, obesity, and even some cancers. Drawbacks of the vegan diet When you eliminate all animal products from your diet, it can be difficult to get enough of certain nutrients, like vitamin B-12 and iron. Experts recommend taking a certified B12 supplement and consulting with your healthcare provider if you experience any symptoms of B12 deficiency, such as: Cognitive changes like depression, fatigue, and memory impairment Muscle weakness Breathlessness Weight loss Increased heart rate While it’s certainly possible to get enough protein from plant sources, you may have to think creatively at first and explore other options like tofu, tempeh, lentils, plant-based milks, nuts, and seeds. The bottom line: What’s the best diabetes diet for blood sugar management? No eating plan or pattern for diabetes is magical. However, with careful consideration and an understanding of your personal goals, preferences, and capacity to adjust, one of these meal patterns may be right for you. Combining one of these eating patterns with the diabetes plate method – a recommendation of half non-starchy vegetables, one-quarter protein, and one-quarter carbohydrate foods – can help you create balanced, healthy meals and manage blood sugar. Of course, it’s important to combine healthy meals with physical activity to support blood glucose control, maintain a healthy weight, and reduce the risk of diabetes complications. If you’re looking for assistance with meal planning, a registered dietitian and CDCES can help. Here is a helpful database to find a CDCES who can work with you.
December 30, 2024
Ever been in a situation where someone just didn’t get it when it comes to diabetes? You’re not alone! In the final video of the Spoonful of Laughter series, comedian Kesha Carter, filmmaker Kelsey Bascom, and diabetes creator Justin Eastzer take a hilarious dive into what happens when misunderstandings meet real-life diabetes experiences.
December 16, 2024
If you’re still trying to get in the holiday spirit, there’s nothing better than a seasonally appropriate cocktail to sip on this time of year. I’ve created three cocktails that feature nostalgic childhood flavors and garnishes meant to wow but also utilize lower-carb ingredients. Enjoy these all season long – with little insulin required! 
A row of spoons filled with different types of spices.
December 11, 2024
Could the spices in your kitchen cabinet protect or even improve brain health? Research suggests spices contain properties beneficial to health, plus they add wonderful flavor and depth to any dish.
A magnifying glass with the word diabetes on it
December 11, 2024
The American Diabetes Association (ADA) recently released their 2025 Standards of Care, which – for the first time – includes recommendations for CGM use in type 2 diabetes, the use of GLP-1 drugs for kidney and heart health, and more.
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